118 IDENTIFYING CHRONIC PROSTATITIS/ CHRONIC PELVIC PAIN SYNDROME FOR EPIDEMIOLOGIC STUDIES

Abstract

You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Evidence-based Medicine & Outcomes III1 Apr 2010118 IDENTIFYING CHRONIC PROSTATITIS/ CHRONIC PELVIC PAIN SYNDROME FOR EPIDEMIOLOGIC STUDIES J. Quentin Clemens, Lara Hilton, Marika Suttorp, and Sandra Berry J. Quentin ClemensJ. Quentin Clemens Ann Arbor, MI More articles by this author , Lara HiltonLara Hilton Santa Monica, CA More articles by this author , Marika SuttorpMarika Suttorp Santa Monica, CA More articles by this author , and Sandra BerrySandra Berry Santa Monica, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.168AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Nickel and colleagues1 used responses from the NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) to identify the presence of symptoms indicative of chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS). Since then, numerous other investigators have used this definition to report the prevalence of CP/CPPS symptoms. However, the sensitivity and specificity of this definition in relation to clinical diagnoses has not been assessed. METHODS Responses from the 434 subjects (151 CP/CPPS, 149 benign prostatic hyperplasia (BPH), and 134 controls) who comprised the original NIH-CPSI validation set were examined. CP/CPPS symptoms were defined per the Nickel definition as follows: the presence of perineal or ejaculatory pain, plus a score of ≥4 on the NIH-CPSI pain subscale. We calculated the fraction of diagnosed CP/CPPS cases that were correctly identified as having CP/CPPS symptoms (sensitivity), and the fraction of non-CP/CPPS cases that were correctly identified as not CP/CPPS (specificity). RESULTS Results are presented in the Table. The sensitivity of the definition was 70%. The specificity was 91% when compared with BPH patients, and 99% when compared with controls. CP/CPPS BPH Controls Met case definition criteria 105 13 1 119 Did not meet case definition criteria 46 136 133 315 Total 151 149 134 434 CONCLUSIONS The Nickel et al case definition appears to have excellent specificity for distinguishing CP/CPPS from BPH and controls. The sensitivity is also reasonably high, especially considering that CP/CPPS is a clinical syndrome without an objective diagnostic marker. References 1 : Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index. J Urol2001; 165: 842. Link, Google Scholar © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited bySuskind A, Berry S, Ewing B, Elliott M, Suttorp M and Clemens J (2018) The Prevalence and Overlap of Interstitial Cystitis/Bladder Pain Syndrome and Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Men: Results of the RAND Interstitial Cystitis Epidemiology Male StudyJournal of Urology, VOL. 189, NO. 1, (141-145), Online publication date: 1-Jan-2013. Volume 183Issue 4SApril 2010Page: e48 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information J. Quentin Clemens Ann Arbor, MI More articles by this author Lara Hilton Santa Monica, CA More articles by this author Marika Suttorp Santa Monica, CA More articles by this author Sandra Berry Santa Monica, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...