MP21-12 HEALTH RELATED QUALITY OF LIFE FOLLOWING RADICAL CYSTECTOMY: COMPARATIVE ANALYSIS FROM THE MEDICAL HEALTH OUTCOMES STUDY

Abstract

You have accessJournal of UrologyBladder Cancer: Invasive I1 Apr 2017MP21-12 HEALTH RELATED QUALITY OF LIFE FOLLOWING RADICAL CYSTECTOMY: COMPARATIVE ANALYSIS FROM THE MEDICAL HEALTH OUTCOMES STUDY Brian Winters, George Schade, Sarah Holt, Atreya Dash, John Gore, and Jonathan Wright Brian WintersBrian Winters More articles by this author , George SchadeGeorge Schade More articles by this author , Sarah HoltSarah Holt More articles by this author , Atreya DashAtreya Dash More articles by this author , John GoreJohn Gore More articles by this author , and Jonathan WrightJonathan Wright More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.3274AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Health related quality of life (HRQOL) after radical cystectomy and ileal conduit (RC-IC) is not well quantified at the population level. Given the large extirpative nature of the surgery combined with stoma creation, this is a life-changing event for patients. We evaluated post-RC-IC HRQOL in patients with bladder cancer (BC) compared with non-cancer controls and colorectal cancer (CRC) patients undergoing proctocolectomy with colostomy using SEER-Medical Health Outcomes Survey (MHOS) data. METHODS SEER-MHOS data (1998-2013) was used to identify patients with BC and CRC diagnoses and survey data available post diagnoses. 196 BC patients undergoing RC-IC were propensity score matched 1:5 to non-cancer controls (N=980) and compared with 154 CRC patients undergoing proctocolectomy with colostomy. Differences in mental and physical composite scores (MCS and PCS, respectively) were compared between groups. MCS and PCS scores are normalized on a 0-100 scale where 50 represents US population mean. RESULTS RC-IC patients, compared with matched controls, had significantly lower PCS (35.9 vs. 40.2, p<0.001), physical functioning (52.6 vs. 62.4, p<0.001), role physical (41.2 vs. 54.0, p<0.001), social functioning (69.7 vs. 76.3, p=0.006), vitality (51.1 vs. 56.3, p=0.005), and general health (51.8 vs. 62.0, p<0.001). MCS and mental health subscale scores did not differ between groups. Comparing RC-IC patients with CRC patients, female gender (26 vs. 38%, p=0.01) and inflammatory bowel disease (6% vs. 14%, p=0.005) were more common in CRC patients. MCS, PCS, and HRQOL subscales did not differ between RC-IC and CRC patients. Among a subset of RC-IC patients with both pre and post-surgical data (N=46), PCS (p=0.002), physical functioning (p=0.04), social functioning (p=0.02), and general health (p<0.001) declined significantly. CONCLUSIONS RC-IC patients have worsened HRQOL than non-cancer controls. However, HRQOL of RC-IC patients was similar to that of CRC patients undergoing proctocolectomy with colostomy. Further longitudinal study is needed to better quantify HRQOL in RC-IC. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e252 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Brian Winters More articles by this author George Schade More articles by this author Sarah Holt More articles by this author Atreya Dash More articles by this author John Gore More articles by this author Jonathan Wright More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...