262 UTILITY-BASED ASSESSMENT OF HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN PATIENTS WITH KIDNEY STONES

Abstract

You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Quality of Life1 Apr 2010262 UTILITY-BASED ASSESSMENT OF HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN PATIENTS WITH KIDNEY STONES Ephrem Olweny, Sara Knight, Brian Eisner, Peter Carroll, and Marshall Stoller Ephrem OlwenyEphrem Olweny San Francisco, CA More articles by this author , Sara KnightSara Knight San Francisco, CA More articles by this author , Brian EisnerBrian Eisner Boston, MA More articles by this author , Peter CarrollPeter Carroll San Francisco, CA More articles by this author , and Marshall StollerMarshall Stoller San Francisco, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.322AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Health-related quality of life (HRQOL) is an important consideration in treatment selection for kidney stones, given the controversy surrounding the choice of an optimal first-line treatment modality in certain clinical situations. To conduct economic analyses of the burden of stone disease with respect to HRQOL, health utilities are required, but have previously not been reported for patients with kidney stones. We herein report the first utility-based assessment of HRQOL in patients with kidney stones. METHODS After institutional review board approval, a cross-sectional survey of HRQOL in stone patients followed at our Endourology practice was performed using the SF-36 v2 questionnaire. Patient demographic, clinical, and treatment data were also collected. Patient SF-36 scores were compared to those for the U.S. general population using the Student's t-test. Health utility score (range 0 (death) to 1 (perfect health)) for each patient was measured using the SF-6D, a multi-attribute indirect utility instrument based on the SF-36. The average utility score for the patient cohort is reported. RESULTS 97 stone patients were surveyed. Mean age and BMI (±SD) respectively were 53.6 (±15.3) years and 28.1 (±7.2). 61% were male, 63% were white, 39% had a Charlson comorbidity index of 1 or higher, and 77% were recurrent stone formers. 72% were pain-free at time of sampling, and 74% had undergone at least one prior surgical intervention. 36% reported a history of prior or current medical treatment. These clinical characteristics were similar those for stone patients for whom HRQOL has previously been reported. As compared to the U.S general population, stone patients had significantly lower scores in 5/8 domains of the SF-36 (physical functioning, role physical, social functioning, bodily pain and general health perception), as well as the physical composite score (p<0.05 for each). The mean health utility score (±SD) for our patient cohort was 0.65 (±0.11). CONCLUSIONS HRQOL as measured by the SF-36 is decreased in stone patients, consistent with previous reports. A parallel decrease in health utility was detected and quantified by the SF-6D, suggesting that it is sensitive to HRQOL changes assessed by stone patients, and is thus a feasible tool for measuring utilities in this patient group. Measurement of health utilities using a variety of alternate methods is recommended for comparative evaluation. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e103 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ephrem Olweny San Francisco, CA More articles by this author Sara Knight San Francisco, CA More articles by this author Brian Eisner Boston, MA More articles by this author Peter Carroll San Francisco, CA More articles by this author Marshall Stoller San Francisco, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...