MP20-15 THE ACCURACY OF 68GALLIUM-PSMA PET/CT IN PRIMARY LYMPH NODE STAGING FOR HIGH RISK PROSTATE CANCER

Abstract

You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2017MP20-15 THE ACCURACY OF 68GALLIUM-PSMA PET/CT IN PRIMARY LYMPH NODE STAGING FOR HIGH RISK PROSTATE CANCER Can Obek, Tunkut Doganca, Emre Demirci, Meltem Ocak, Ali Riza Kural, Asif Yildirim, Ugur Yucetas, Cetin Demirdag, Sarper M. Erdogan, and Levent Kabasakal Can ObekCan Obek More articles by this author , Tunkut DogancaTunkut Doganca More articles by this author , Emre DemirciEmre Demirci More articles by this author , Meltem OcakMeltem Ocak More articles by this author , Ali Riza KuralAli Riza Kural More articles by this author , Asif YildirimAsif Yildirim More articles by this author , Ugur YucetasUgur Yucetas More articles by this author , Cetin DemirdagCetin Demirdag More articles by this author , Sarper M. ErdoganSarper M. Erdogan More articles by this author , and Levent KabasakalLevent Kabasakal More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.647AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES PSMA/PET CT is a novel molecular imaging for accurate staging of prostate cancer. Its role has been mostly investigated in post-treatment setting. We assessed the diagnostic accuracy of 68Gallium-PSMA PET to predict LN metastases in primary N-staging in high andvery high-risk non-metastatic prostate cancer in comparison with morphologic imaging. METHODS This was a multi-centric trial of the Society of Urologic Oncology in Turkey in conjunction with Nuclear Medicine Department at Cerrahpasa School of Medicine, Istanbul University. Patients were accrued from 8 centers. High and very high-risk patientsscheduled to undergo surgical treatment with extended LN dissection between July 2014 and October 2015 were included. Morphological imaging was with either MRI/CT. PSMA PET-CT was performed and evaluated at a single center. Sensitivity, specificity and accuracywere calculated for the detection of lymphatic metastases for PSMA PET/CT and morphological imaging. Kappa values were calculated for pathological and radiological incidence of LN metastases. RESULTS Data on 51 eligible patients are presented. Sensitivity, specificity and accuracy of PSMA PET to detect LN metastases in primary setting were 53%, 86%, and 76% and increased to 67%, 88% and 81% in a sub-group with =15 LN removed. Kappa values for correlation of imaging and pathology was 0.41 for PSMA PET and 0.18 for morphological imaging. CONCLUSIONS PSMA/PET CT is superior to morphological imaging for the detection of metastatic LNs in primary prostate cancer setting. Surgical dissection remains to be the gold standard for precise lymphatic staging. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e244-e245 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Can Obek More articles by this author Tunkut Doganca More articles by this author Emre Demirci More articles by this author Meltem Ocak More articles by this author Ali Riza Kural More articles by this author Asif Yildirim More articles by this author Ugur Yucetas More articles by this author Cetin Demirdag More articles by this author Sarper M. Erdogan More articles by this author Levent Kabasakal More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...