MP18-07 THE ACCURACY AND VALIDATION OF MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING (MPMRI) USING PI-RADS V2 IN DISEASE UPGRADING ON RE-BIOPSY AMONG PATIENTS WITH LOW-RISK PROSTATE CANCER ON ACTIVE SURVEILLANCE (AS) – A BRAZILIAN PERSPECTIVE.

Abstract

You have accessJournal of UrologyImaging/Radiology: Uroradiology III1 Apr 2017MP18-07 THE ACCURACY AND VALIDATION OF MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING (MPMRI) USING PI-RADS V2 IN DISEASE UPGRADING ON RE-BIOPSY AMONG PATIENTS WITH LOW-RISK PROSTATE CANCER ON ACTIVE SURVEILLANCE (AS) – A BRAZILIAN PERSPECTIVE. Públio Viana, Natally Horvat, Rodrigo Pessoa, Thiana Rodrigues, Giuliano Guglielmetti, Rafael Coelho, Rubens Park, Herbert Alberto Vargas, and Willian Nahas Públio VianaPúblio Viana More articles by this author , Natally HorvatNatally Horvat More articles by this author , Rodrigo PessoaRodrigo Pessoa More articles by this author , Thiana RodriguesThiana Rodrigues More articles by this author , Giuliano GuglielmettiGiuliano Guglielmetti More articles by this author , Rafael CoelhoRafael Coelho More articles by this author , Rubens ParkRubens Park More articles by this author , Herbert Alberto VargasHerbert Alberto Vargas More articles by this author , and Willian NahasWillian Nahas More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.617AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The current selection criteria to AS is critical, it becomes even more relevant in Latin America, given the higher proportion of high risk cancers.The objective of this study is to analyze the accuracy of mpMRI using PI-RADS v2 in predicting the risk of upgrading on re-biopsy (UR) in men with low-risk PCa on AS. METHODS In this Institutional Review Board approved prospective study, patients with low-grade PCa selected for AS at our institution underwent mpMRI at least 6 weeks after the baseline 12-core random prostate biopsy (BSB), from March 2014 to March 2016. One blinded abdominal radiologist evaluated the exams regarding presence of dominant lesion and assigned the PI-RADS v2 score. MRI-target TRUS guided re-biopsies were done in all patients within 6-12 months after the BSB. Standardized 12-core biopsy was performed and additional cores were taken from suspicious areas on mpMRI. RESULTS One hundred and nine patients were included, 93 (85.3%) patients had a dominant lesion on MRI. mpMRI were classified as PI-RADS 1, 2 or 3 in 67 (61.5%) patients, and as PI-RADS 4 or 5 in 42 (38.5%) patients. UR occurred in 42 (38.5%) patients. Out of these, 39 (92.8%) had radical prostatectomy, 6 (15.4%) T2a, 24 (61.5%) T2b, and 9 (23.1%) T3a. The proportion of UR among PI-RADS categories is shown in table 1. The diagnostic performance of mpMRI for PCa upgrading after re-biopsy was summarized in table 2. Patients assigned as PI-RADS 4 or 5 presented a significantly higher risk for UR compared with patients with PI-RADS 1, 2 or 3 (73.8% vs 16.4%, p<0.001). Logistic regression analyses demonstrated that PI-RADS 4 or 5 remained a significant predictor of UR (OR: 37.366, p<0.0001). CONCLUSIONS We demonstrated in our population that mpMRI using PI-RADS v2 is a significant predictor for upgrading on re-biopsy in patients on AS and could be used to guide TRUS biopsy, increasing the accuracy of current clinical criteria for AS. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e222 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Públio Viana More articles by this author Natally Horvat More articles by this author Rodrigo Pessoa More articles by this author Thiana Rodrigues More articles by this author Giuliano Guglielmetti More articles by this author Rafael Coelho More articles by this author Rubens Park More articles by this author Herbert Alberto Vargas More articles by this author Willian Nahas More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...