MP18-03 PREDICTORS OF LOCAL DISEASE CONTROL AFTER SALVAGE WHOLE GLAND PROSTATE CRYOABLATION

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy1 Apr 2016MP18-03 PREDICTORS OF LOCAL DISEASE CONTROL AFTER SALVAGE WHOLE GLAND PROSTATE CRYOABLATION Yaw Nyame, Ahmed Elshafei, Hans Aurora, Robert W. Given, Thomas J. Polascik, Ashley E. Ross, Vladimir B. Mouraviev, and J. Stephen Jones Yaw NyameYaw Nyame More articles by this author , Ahmed ElshafeiAhmed Elshafei More articles by this author , Hans AuroraHans Aurora More articles by this author , Robert W. GivenRobert W. Given More articles by this author , Thomas J. PolascikThomas J. Polascik More articles by this author , Ashley E. RossAshley E. Ross More articles by this author , Vladimir B. MouravievVladimir B. Mouraviev More articles by this author , and J. Stephen JonesJ. Stephen Jones More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2704AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The objective of this study was to assess factors that affect prostate biopsy results following salvage whole gland cryoablation METHODS A retrospective analysis of 174 patients who underwent transrectal ultrasound-guided biopsy following salvage whole gland cryoablation of the prostate was performed using the Cryo OnLine Database (COLD). Covariates analyzed included age, ethnicity, initial prostate specific antigen (PSA), clinical stage, Gleason score, D Amico risk stratification, neoadjuvant therapy, PSA nadir, time to nadir, and achievement of undetectable PSA level (<0.2ng/ml). Univariate was performed using Wilcoxon rank-sum test for continuous variables and χ2 test for categorical variables. A multivariate logistic regression analysis was also performed. RESULTS 52/174 (29.8%) patients who underwent prostate biopsy had a positive result following salvage cryoablation with a median time of 11 months to biopsy. On univariate analysis, patients with positive biopsy were more likely to be in the D Amico high-risk category (69.2% vs. 45.9%), more likely to have a higher median PSA nadir (0.7 vs. 0.1, P=0.0001), and less likely to have an undetectable PSA prior to PSA (25.4% vs.57.02%, P= 0.0002). On multivariate analysis, PSA nadir (OR 1.08, P=0.0132) was the only independent factor of post-operative biopsy outcome (Table 1). CONCLUSIONS PSA nadir level following salvage whole gland cryoablation was the only factor that was independently associated with prostate biopsy outcomes on multivariate analysis. This may guide the need for prostate biopsy when local failure following salvage whole gland cryoablation is suspected © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e193 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Yaw Nyame More articles by this author Ahmed Elshafei More articles by this author Hans Aurora More articles by this author Robert W. Given More articles by this author Thomas J. Polascik More articles by this author Ashley E. Ross More articles by this author Vladimir B. Mouraviev More articles by this author J. Stephen Jones More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...