MP14-20 SHORT PEAK EXPOSURE TO AMBIENT FINE PARTICULATE MATTER PROBABLY CONTRIBUTED TO INCREASED PROSTATE CANCER MORTALITY

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History III1 Apr 2015MP14-20 SHORT PEAK EXPOSURE TO AMBIENT FINE PARTICULATE MATTER PROBABLY CONTRIBUTED TO INCREASED PROSTATE CANCER MORTALITY Xiaojian Qin, Fangning Wan, Hailiang Zhang, Bo Dai, Guohai Shi, Yao Zhu, and Dingwei Ye Xiaojian QinXiaojian Qin More articles by this author , Fangning WanFangning Wan More articles by this author , Hailiang ZhangHailiang Zhang More articles by this author , Bo DaiBo Dai More articles by this author , Guohai ShiGuohai Shi More articles by this author , Yao ZhuYao Zhu More articles by this author , and Dingwei YeDingwei Ye More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.882AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prostate cancer (PCa) is the most common and most lethal cancer in male urogenital system. Insufficient convincing data addressed the association between ambient fine particulate matter (PM2.5) exposure and PCa. METHODS County-level PM2.5 concentrations from 2001 to 2010 were downloaded from the US EPA Air Quality Statistics Report. Annual county-level PM2.5 concentrations includes the 98th percentile (%ile) of the daily average measurements and the weighted annual mean (Wtd Mean). County-level PCa profiles includes age-standardized annual incidence rates and annual mortality rates for all races, including Hispanics, from 2006 to 2010. The incidence and mortality rates of PCa were compared with PM2.5 concentrations, alone, and adjusted by the population and neighborhood county-level socioeconomic status (SES) information. RESULTS Unadjusted linear regression analyses indicated higher levels of average PM2.5 Wtd Means and average PM2.5 98th %ile values in period of 2001 to 2005 were associated with higher incidence (p<0.05), higher levels of average PM2.5 Wtd Means in period of both 2001 to 2005 and 2006 to 2010 were associated with higher mortality (p<0.05). However, when adjusted by the population and SES information, only higher levels of average PM2.5 98th %ile in 2006 to 2010 were associated with increased mortality, and the adjusted slope was 0.06 (95% CI 0.01, 0.11, p = 0.015) per 1 ¦Ìg/m3 average PM2.5 98th %ile in 2006 to 2010 for PCa mortality. CONCLUSIONS There was a possible association between ambient PM2.5 concentrations and PCa, and short peaks of PM2.5 exposure most probably contributed to increased mortality in PCa. If confirmed, campaigns against PCa should be at the forefront of global public health concerns, and this primary work from us Urologists will transcend the boundaries of institutions and countries. This pilot study should severe as an alarm, not only to the US, but also to other populations across the world and cancers of other sites. Even before going that far, as Urologists, we may cautiously inform our patients with PCa to avoid daily exposure to high levels of PM2.5 concentrations by now. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e158 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Xiaojian Qin More articles by this author Fangning Wan More articles by this author Hailiang Zhang More articles by this author Bo Dai More articles by this author Guohai Shi More articles by this author Yao Zhu More articles by this author Dingwei Ye More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...