MP43-18 PROSTATE CANCER MORTALITY RATES IN LOW AND FAVORABLE INTERMEDIATE RISK ACTIVE SURVEILLANCE PATIENTS: A POPULATION-BASED COMPETING RISKS ANALYSIS

Abstract

You have accessJournal of UrologyCME1 May 2022MP43-18 PROSTATE CANCER MORTALITY RATES IN LOW AND FAVORABLE INTERMEDIATE RISK ACTIVE SURVEILLANCE PATIENTS: A POPULATION-BASED COMPETING RISKS ANALYSIS Rashid Sayyid, John Benton, William Reed, Merry Ma, Phillip Woodruff, Martha Terris, Christopher Wallis, and Zachary Klaassen Rashid SayyidRashid Sayyid More articles by this author , John BentonJohn Benton More articles by this author , William ReedWilliam Reed More articles by this author , Merry MaMerry Ma More articles by this author , Phillip WoodruffPhillip Woodruff More articles by this author , Martha TerrisMartha Terris More articles by this author , Christopher WallisChristopher Wallis More articles by this author , and Zachary KlaassenZachary Klaassen More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002609.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Active surveillance (AS) use is recommended for low and select favorable intermediate risk (FIR) prostate cancer (PCa) patients. PCa mortality rates, and thus suitability of AS, in individual FIR subgroups remain undefined. Our objective was to determine PCa and other-cause mortality rates in low and FIR AS patients. METHODS: The Surveillance, Epidemiology, and End Results Prostate with Watchful Waiting database was used to identify men diagnosed with NCCN low or FIR PCa between 2010 and 2015, managed initially with AS. Patients in the FIR group were subdivided into three risk subgroups depending on their intermediate risk factor: Grade Group (GG) two disease, prostate-specific antigen (PSA) level 10-20 ng/ml and cT2b-c. Cumulative incidence function curves with other-cause mortality as the competing risk were utilized. Multivariable regression analyses using Fine and Gray’s semi-parametric proportional hazards model were used to assess predictors of PCa mortality. RESULTS: Among 70,871 patients, 48,127 (67.9%) had low and 22,744 (32.1%) had FIR disease. Median follow up was 49.0 months. There were 166 (0.2%) PCa and 3,176 (4.48%) other-cause mortalities. The five-year PCa mortality rates in the low and FIR cohorts overall were 0.29% and 0.28%, respectively (p=0.64). Within the FIR cohort, the corresponding rates were highest in the PSA 10-20 ng/ml subgroup at 0.73%, followed by 0.32% for Grade Group 2 FIR and 0.052% for cT2b-c FIR disease (p<0.001).On multivariable analysis, patients with Medicaid insurance (subdistribution hazard ratio [sHR]: 2.58, p=0.006), lowest SES (sHR:1.39, p=0.032), older age at diagnosis (sHR: 2.38, p=0.006), unmarried (sHR: 2.58, p<0.001), GG2 disease on initial biopsy (sHR: 1.17, p=0.048) and serum PSA level at diagnosis of 10-20 ng/ml (sHR: 2.09, p=0.032) had a significantly increased PCa mortality hazard. Patients undergoing definitive therapy with either RP or definitive XRT did not have a significantly different PCa mortality hazard (sHR 0.70, p=0.14). CONCLUSIONS: Intermediate-term PCa mortality rates in FIR PCa patients appear to be similar to those with low risk PCa. However, there is significant within-group heterogeneity with PCa mortality rates significantly higher in PSA 10-20 FIR PCa patients. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e748 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rashid Sayyid More articles by this author John Benton More articles by this author William Reed More articles by this author Merry Ma More articles by this author Phillip Woodruff More articles by this author Martha Terris More articles by this author Christopher Wallis More articles by this author Zachary Klaassen More articles by this author Expand All Advertisement PDF DownloadLoading ...