MP13-08 THE COMPARISON ONE IMMEDIATE POSTOPERATIVE INTRAVESICAL CHEMOTHERAPY WITH SHORT-TERM ADJUVANT INTRAVESICAL CHEMOTHERAPY AFTER TURBT IN LOW- AND INTERMEDIATE RECURRENT RISK OF NON-MUSCLE-INVASIVE BLADDER CANCER- A RANDOMIZED PROSPECTIVE STUDY IN JAPAN.

Abstract

You have accessJournal of UrologyBladder Cancer: Non-Invasive I1 Apr 2016MP13-08 THE COMPARISON ONE IMMEDIATE POSTOPERATIVE INTRAVESICAL CHEMOTHERAPY WITH SHORT-TERM ADJUVANT INTRAVESICAL CHEMOTHERAPY AFTER TURBT IN LOW- AND INTERMEDIATE RECURRENT RISK OF NON-MUSCLE-INVASIVE BLADDER CANCER- A RANDOMIZED PROSPECTIVE STUDY IN JAPAN. Yoshio Naya, Takumi Shiraishi, Masakatsu Oishi, Takashi Ueda, Hiroyuki Nakanshi, Yasuyuki Naitoh, Terukazu Nakamura, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Kazuya Mikami, Tsuyoshi Iwata, and Osamu Ukimura Yoshio NayaYoshio Naya More articles by this author , Takumi ShiraishiTakumi Shiraishi More articles by this author , Masakatsu OishiMasakatsu Oishi More articles by this author , Takashi UedaTakashi Ueda More articles by this author , Hiroyuki NakanshiHiroyuki Nakanshi More articles by this author , Yasuyuki NaitohYasuyuki Naitoh More articles by this author , Terukazu NakamuraTerukazu Nakamura More articles by this author , Fumiya HongoFumiya Hongo More articles by this author , Kazumi KamoiKazumi Kamoi More articles by this author , Koji OkiharaKoji Okihara More articles by this author , Kazuya MikamiKazuya Mikami More articles by this author , Tsuyoshi IwataTsuyoshi Iwata More articles by this author , and Osamu UkimuraOsamu Ukimura More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2489AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We conducted a randomized, prospective, multicenter study comparing one immediate postoperative intravesical chemotherapy with short-term adjuvant intravesical chemotherapy after transurethral resection of bladder tumor (TURBT) in non-muscle invasive bladder carcinoma (NMIBC) with low or intermediate recurrent risk. The objective is to evaluate the efficacy of intravesical chemotherapy using pirarubicin for patients with low or intermediate risk. METHODS This study was approved by the ethics committees of Kyoto Prefectural University of Medicine in September 2010. The recurrent risk was stratified using EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update. Between October 2010 and January 2015, 216 patients was enrolled in this study and 97 patients were excluded from this study after TURBT for their high recurrent risk of NMIBC. Remaining 109 with low or intermediate recurrent risk of NMIBC were randomized to one immediate postoperative intravesical instillation of pirarubicin (THP) 30mg (Group A), or additional intravesical chemotherapy of THP 30mg weekly for 8 weeks (Group B). The patients were examined by cystoscopy and urine cytological examination every 3 months after TURBt to determine bladder tumor recurrence. RESULTS The 2-year recurrence free rate were 65.3% for Group A and 87.2% for Group B, respectively (log rank test, p = 0.038). In patients with intermediate recurrent risk, the 2year recurrence free rate were 62.3% in Group A and 86.8% in group B, respectively (log rank test, p = 0.0261). In patients with recurrent score between 5 and 9, the 2-year recurrence free rate were 91.7% in Group A and 25.0% in Group B (log rank test, p=0.0052). There was no patient with progression during this period. Adverse events were documented in 0% and 24.4% in Group A and Group B, respectively. There was no patient with severe adverse event (Grade 3 or more). CONCLUSIONS Additional instillation of THP 30mg weekly for 8 weeks reduced the risk of tumor recurrence without severe toxicity in NMIBC patients with intermediate recurrent risk. Our data provide a rationale for adjuvant intravesical chemotherapy after TURBT in NMIBC patients with intermediate recurrent risk. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e137 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Yoshio Naya More articles by this author Takumi Shiraishi More articles by this author Masakatsu Oishi More articles by this author Takashi Ueda More articles by this author Hiroyuki Nakanshi More articles by this author Yasuyuki Naitoh More articles by this author Terukazu Nakamura More articles by this author Fumiya Hongo More articles by this author Kazumi Kamoi More articles by this author Koji Okihara More articles by this author Kazuya Mikami More articles by this author Tsuyoshi Iwata More articles by this author Osamu Ukimura More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...