MP09-02 MULTIPARAMETRIC MRI-BASED RADIOMICS FEATURES OF PROSTATIC ADENOCARCINOMA WITH CRIBRIFORM ARCHITECTURE

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP09-02 MULTIPARAMETRIC MRI-BASED RADIOMICS FEATURES OF PROSTATIC ADENOCARCINOMA WITH CRIBRIFORM ARCHITECTURE Zoe Blake, Mason Belue, Daniel Nemirovsky, Stephanie Harmon, Jacob Enders, Alexander Kenigsberg, Neil Mendhiratta, Enis Yilmaz, Yue Lin, Michael Rothberg, Antoun Toubaji, Maria Merino, Sandeep Gurram, Bradford Wood, Peter Choyke, Baris Turkbey, and Peter Pinto Zoe BlakeZoe Blake More articles by this author , Mason BelueMason Belue More articles by this author , Daniel NemirovskyDaniel Nemirovsky More articles by this author , Stephanie HarmonStephanie Harmon More articles by this author , Jacob EndersJacob Enders More articles by this author , Alexander KenigsbergAlexander Kenigsberg More articles by this author , Neil MendhirattaNeil Mendhiratta More articles by this author , Enis YilmazEnis Yilmaz More articles by this author , Yue LinYue Lin More articles by this author , Michael RothbergMichael Rothberg More articles by this author , Antoun ToubajiAntoun Toubaji More articles by this author , Maria MerinoMaria Merino More articles by this author , Sandeep GurramSandeep Gurram More articles by this author , Bradford WoodBradford Wood More articles by this author , Peter ChoykePeter Choyke More articles by this author , Baris TurkbeyBaris Turkbey More articles by this author , and Peter PintoPeter Pinto More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003224.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Cribriform (CBFM) pattern on prostate biopsy has been implicated as a predictor for high-risk features, potentially leading to adverse outcomes after definitive treatment. Literature on imaging characteristics of CBFM is sparse and mixed. This study aims to elucidate the multiparametric MRI (mpMRI) features of CBFM-containing cancers on prostate biopsy using radiomics. METHODS: Patients who underwent mpMRI, combined 12-core transrectal ultrasound (TRUS) guided systematic and MRI/US fusion-guided biopsy on a prostate cancer (PCa) clinical trial were retrospectively queried for the presence of CBFM pattern at biopsy. Biopsy cores were scored: C0=benign, C1=PCa with no CBFM pattern, C2=PCa with CBFM pattern. In addition to targeted lesion regions of interest (ROIs), patient-specific 12-core systematic TRUS biopsy sector maps were reconstructed and transposed on mpMRI slices for virtual core ROI creation (Figure 1). Radiomics features from each ROI were extracted using PyRadiomics package in Python. Radiomics and clinical feature analyses were done with Wilcoxon signed-rank test and Akaike Information Criterion. RESULTS: Between 2020-2022, 90 consecutive patients with CBFM pattern on prostate biopsy and paired mpMRI were identified. Radiomics/clinical feature analysis included 1080 transrectal systematic biopsy cores (677 C0, 191 C1, 212 C2) and 272 MRI-targeted biopsy cores (72 C0, 66 C1, 134 C2). On combined biopsy analysis, two DWI radiomics features capturing signal heterogeneity were predictive for CBFM classification (p<.01). On analysis of MRI-targeted biopsy only, overall PIRADS score (p=.037), DWI PIRADS score (p=.017), and target lesion dimension (p=.017) were predictive for CBFM classification (Table 1). CONCLUSIONS: CBFM pattern has visible radiomics features on mpMRI, most notably on DWI. Imaging findings suggestive of CBFM may play a role in risk stratification and patient counseling. Further studies are needed to evaluate these lesions and validate their imageability longitudinally and externally. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e103 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Zoe Blake More articles by this author Mason Belue More articles by this author Daniel Nemirovsky More articles by this author Stephanie Harmon More articles by this author Jacob Enders More articles by this author Alexander Kenigsberg More articles by this author Neil Mendhiratta More articles by this author Enis Yilmaz More articles by this author Yue Lin More articles by this author Michael Rothberg More articles by this author Antoun Toubaji More articles by this author Maria Merino More articles by this author Sandeep Gurram More articles by this author Bradford Wood More articles by this author Peter Choyke More articles by this author Baris Turkbey More articles by this author Peter Pinto More articles by this author Expand All Advertisement PDF downloadLoading ...