MP07-18 THE PREVALENCE OF CALCIUM OXALATE STONES IS DIFFERENT WHEN COMPOSITION ANALYSES ARE FROM WHOLE STONES VERSUS STONE FRAGMENTS

Abstract

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology (MP07)1 Sep 2021MP07-18 THE PREVALENCE OF CALCIUM OXALATE STONES IS DIFFERENT WHEN COMPOSITION ANALYSES ARE FROM WHOLE STONES VERSUS STONE FRAGMENTS Margaret Knoedler, Shuang Li, Sara Best, Sean Hedican, Stephen Nakada, and Kristina Penniston Margaret KnoedlerMargaret Knoedler More articles by this author , Shuang LiShuang Li More articles by this author , Sara BestSara Best More articles by this author , Sean HedicanSean Hedican More articles by this author , Stephen NakadaStephen Nakada More articles by this author , and Kristina PennistonKristina Penniston More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001980.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Stone analysis is a cornerstone of metabolic stone treatment. Our objective was to evaluate if stone composition varied based on whether the specimen was submitted as a whole stone or as fragments of a stone. METHODS: An IRB approved surgical database of patients at a single institution was evaluated for stone analyses between 1997 and 2020. All stone analyses were performed at one of two labs (Dianon Systems and Louis C. Herring Company). Stone analyses were assessed for presence and percent of calcium oxalate. Stones were considered primarily calcium oxalate if the composition was >/=60% calcium oxalate. We used univariate analysis with chi-square and independent T test to compare percentage of stone specimens submitted as calcium oxalate as well as frequency of primarily calcium oxalate stones submitted as whole stones versus fragments. RESULTS: Of the 4664 stone specimens analyzed, 4179 specimens contained any amount of calcium oxalate and 3209 were primarily calcium oxalate stones. When comparing all specimens containing calcium oxalate submitted as whole stones versus fragments of stones, there was a statistical difference between the percent of specimen that was calcium oxalate (78.6±29.2 vs 64.7±34.6 percent; p <0.001). See table 1. For primarily calcium oxalate stones, the frequency of stones submitted as whole stones versus fragments also differed significantly (77.8% vs 62%, p <0.001). See table 2. CONCLUSIONS: The frequency and percentage of calcium oxalate stones differs when specimens are submitted as fragments compared to whole stones. Specimens submitted as whole stones had a higher percentage of calcium oxalate than specimens submitted as fragments. Most stones are heterogenous in nature and when stones are submitted as fragments, stone composition assessment may be compromised. This is significant as stone composition leads to clinical decisions on metabolic stone treatment. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e146-e147 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Margaret Knoedler More articles by this author Shuang Li More articles by this author Sara Best More articles by this author Sean Hedican More articles by this author Stephen Nakada More articles by this author Kristina Penniston More articles by this author Expand All Advertisement Loading ...