Abstract
In recent years, interest has increased in the role of homocysteine and folate, as modulators of fertility status. The human methylenetetrahydrofolate reductase (MTHFR) gene plays a crucial role in folate metabolism. Data regarding the influence of MTHFR gene polymorphisms on male fertility status are scarce and conflicting. We determined associations between three MTHFR gene polymorphisms (C677T, A1298C, and G1793A), serum folate and total homocysteine (tHcy) levels, with male fertility status and semen parameters.
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