MP05-06 INDIVIDUALS' STONE COMPOSITION VARIABILITY OVER TIME: SINGLE INSTITUTION STUDY

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP05-06 INDIVIDUALS' STONE COMPOSITION VARIABILITY OVER TIME: SINGLE INSTITUTION STUDY Margaret A. Knoedler, Shuang Li, Ali S Antar, Stephen Y. Nakada, and Kristina L. Penniston Margaret A. KnoedlerMargaret A. Knoedler More articles by this author , Shuang LiShuang Li More articles by this author , Ali S AntarAli S Antar More articles by this author , Stephen Y. NakadaStephen Y. Nakada More articles by this author , and Kristina L. PennistonKristina L. Penniston More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003216.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Stone analysis is important for directing metabolic stone management of patients at risk for recurrent stones. In addition to results from 24 h urine collections, knowledge of stone composition serves as a pathway to diagnosis of underlying disorders. The objective of this study was to assess stone composition over time in patients with at least two composition analyses. METHODS: We retrospectively reviewed data for patients within our health system with stone composition analyses from 1997 to 2022. Patients with ≥2 analyses ≥12 months apart were identified. Stones were collected through spontaneous passage or procedures (shock wave lithotripsy, ureteroscopy, or percutaneous nephrolithotomy). Patients’ predominant stone compositions were defined as the component ≥60% and were otherwise considered mixed. Stones that were 100% organic material were excluded from analysis. Univariate analyses (chi-square, T test) were used to compare patients’ stone analyses. RESULTS: We reviewed 4131 stone analyses and identified 338 patients with 2 or more analyses and 76 patients who had three or more analyses. Patients were 41% female and averaged 51±14 years (min-max 18-84 years) at the time of their first stone composition. Eighty-nine (26.3%) patients had a change in their predominant stone component from the first to second stone; 26 (34.2%) had a change from the first to third stone. The mean time between the first and second stone analyses was 54 months (range 12-188, median 44 months); time between the second and third stone analyses was 76 months (range 14-258, median 61 months). A small number of patients, 3.2% of all calcium oxalate stone formers, changed from predominantly calcium oxalate in the first stone analysis to calcium phosphate in the second. This was not different (p=0.84, Fisher’s exact test) than the number whose stones changed from calcium phosphate in the first stone analysis to calcium oxalate in the second (3.8%) (Figure 1). CONCLUSIONS: Patients’ stone composition demonstrated variability in repetitive analyses. Repeating stone analyses may be an important component of long term medical stone management for individual patients. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e45 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Margaret A. Knoedler More articles by this author Shuang Li More articles by this author Ali S Antar More articles by this author Stephen Y. Nakada More articles by this author Kristina L. Penniston More articles by this author Expand All Advertisement PDF downloadLoading ...