Abstract
We describe fluidic control in lipid nanotubes 50−150 nm in radius, conjugated with surface-immobilized unilamellar lipid bilayer vesicles (∼5−25 μm in diameter). Transport in nanotubes was induced by continuously increasing the surface tension of one of the conjugated vesicles, for example, by ellipsoidal shape deformation using a pair of carbon microfibers controlled by micromanipulators as tweezers. The shape deformation resulted in a flow of membrane lipids toward the vesicle with the higher membrane tension; this lipid flow in turn moved the liquid column inside the nanotube through viscous coupling. Thus, micrometer-sized vesicles are used as a handle for controlling fluid flow inside nanometer-sized channels. We show transport and trapping of a single 30-nm-diameter carboxylate-modified latex particle inside a ∼100-nm-radius nanotube. Fluidic control in nanometer-sized channels using a moving wall provides pluglike liquid flows, offers a means for efficient routing and trapping of small molecules, ...
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