Abstract
Background. Studying of thymic mast cells population in normal state and after stressinduced atrophy. Methods. The study was performed on 80 thymus of white outbred mice with using of histochemistry and immunohistochemistry methods. Sections of embryonic thymus were stained with toluidine blue. Adult mice were given a single injection of 2,5 mg of hydrocortisone for induction of thymic accidental transformation; sections were stained with toluidine blue and alcian blue-safranin. Within of immunohistochemical research paraffin sections of adult thymus were stained with polyclonal antibodies to synaptophysin and tyrosine hydroxylase with alcian blue stain. Results. Mast cells (MCs) appeared in thymus on 19th day of embryonic life and demonstrated mainly a medullar location. In adult animals MCs were observed only in the connective tissue of the capsule, interlobular septa, subcortex and perivascular space. Mast cells matured in thymus after accidental transformation. The localization of developing mast cells was changing from medullar and cortical to capsular. A morphological proximity between nerve terminals and mast cells has been observed in normal adult thymus. Some of these nerves were catecholaminergic. Conclusion. Possible important role of thymic mast cells and mast cellsnerves interaction in normal state and after accidental transformation is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
