Abstract
Studying of thymic mast cells population in normal state and after stress-induced atrophy was a background of this work. Work is performed on 60 thymus of white outbred mice with using of histochemistry and immunohistochemistry methods. Adult mice were given a single injection of 2,5 mg of hydrocortisone for induction of thymic accidental transformation; sections were stained with toluidine blue and alcian blue-safranin. Immunohistochemical reactions for the synaptophysin or tyrosine hydroxylase with alcian blue stain were used for identification of nerve terminals in adult thymus. In adult animals MCs were observed only in the connective tissue of the capsule, interlobular septa, subcortex and perivascular space. Mast cells mature in thymus after accidental transformation. The localization of developing mast cells was changing from medullar and cortical to capsular. A morphological proximity between nerve terminals and mast cells have been observed in normal adult thymus. Some of these nerves are catecholaminergic. Possible important role of thymic mast cells and mast cells-nerves interaction in normal state and after accidental transformation is discussed.
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