Abstract
The pathogenesis of venous thromboembolism (VTE) is still not completely understood. Experimental animals in which human deep vein thrombosis can be modeled are useful tools to investigate the pathogenesis of VTE. Besides the availability of transgenic and genetically modified mice, the use of high frequency ultrasound and intravital microscopy plays an important role in identifying thrombotic processes in mouse models. In this article, an overview about the application of various new technologies and existing mouse models is provided, and the impact of venous side branches on deep vein thrombosis in the mouse model is discussed.
Highlights
Using a mouse model of venous thrombosis, Brühl et al [20] were able to demonstrate the essential influence of neutrophils and monocytes in the initial thrombus formation
Thrombotic processes can be observed in a murine small vein model, for example, in mesenteric veins, or in large veins of the animal model
S28 Gefässchirurgie · Suppl 1 · 2017 chronic processes; the focus is more on observation of chronic stages with the analysis of recanalization and thrombus resolution
Summary
40,000 people die annually in Germany from venous thromboembolism, which is usually the result of deep vein thrombosis [12]. Deep vein thrombosis and resulting pulmonary embolism in the sense of venous thromboembolism (VTE) are among the most common diseases worldwide and are associated with a high mortality rate [11]. The interactions between the vein wall, inflammatory cells, platelets, and coagulation factors play a significant role in the pathogenesis of venous thrombosis. Using a mouse model of venous thrombosis, Brühl et al [20] were able to demonstrate the essential influence of neutrophils and monocytes in the initial thrombus formation. This finding would not have been possible without studies in the mouse model. Anatomical variations in the number of side branches in this area are common
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