Strengths and weaknesses of a new mouse model of thrombosis induced by inferior vena cava stenosis: communication from the SSC of the ISTH

Abstract

Deep vein thrombosis (DVT) is a significant cause of morbidity and mortality throughout the world 1. Risk factors for DVT include major surgery, immobilization, trauma, and cancer, among others 1. Many mouse models of thrombosis have been used to study mechanisms of thrombosis, including those involving small and large veins. In this report from the Animal Models Subcommittee of the ISTH, we summarize the strengths and weaknesses of the inferior vena cava (IVC) stenosis mouse model of venous thrombosis.