Abstract
Background: The epidemiological transition states that degenerative diseases are the main responsible for morbidity and mortality, assuming infectious diseases place. This trend can be explained by interaction between socio- environmental and demographic factors. Understand where Brazil is it’s important in the planning of cost-effective health policies and in reduction of morbidity and mortality. Objectives: Describe the number of deaths from infectious and degenerative neurological diseases between 2009 and 2019 in Brazil. Design and setting: This is an descriptive study considering brazilian deaths for neurological disorders. Methods: Using Ministry of Health database (DATASUS) from 2009 to 2019, mortality of following diseases were analyzed: Meningitis and Encephalitis, as infectous disorders; and Parkinson’s, Alzheimer’s and Epilepsy as degenerative disorders. Data from Human Development Index (HDI) were taken from the United Nations Development Program (UNDP). Proportions were calculated to simplify analysis and correlation between variables were verified using simple linear regression. Results: In the period, HDI increased by 6.4%, while mortality from infectious diseases decreased by 25% and from degenerative disordes grew 132%. Considering infectous disorders, Meningitis decreased by 33%, while Encephalitis increased 64%. In chronic-degenerative diseases, deaths due to Alzheimer’s disease increased by 158%, in Parkinson’s disease 90%, and 63% in Epilepsy. Correlation analysis using simple linear regression revealed a Pearson coefficient (r) of 0.924 and -0.967 for the relation between HDI and mortality from degenerative and infectious diseases, respectively. Conclusion: Brazil has followed the trend of epidemiological transition, with increase in mortality from chronic-degenerative diseases and reduction in infectious disorders.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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