Abstract
Morphometric analysis of megakaryocyte cellular and nuclear size in bone marrow biopsies of 28 cases of acute non-lymphocytic leukemia at diagnosis and 15 controls was performed. Median megakaryocyte cell diameter, median area, and perimeter were less than 95% control range (<18.5 μm, <263 μm 2, <64 μm) in 5/5 of induction failures. Attainment of complete remission was significantly greater in those with median megakaryocyte diameter ≥ 18.5 μm ( p<0.01), median area ≥263 μm ( p < 0.001) and perimeter ≥64 μm ( p < 0.001). Prolonged complete remission was correlated with normal megakaryocyte size with the median megakaryocyte area, median diameter, and perimeter within or greater than the reference range (≥18.5 μm, ≥263 μm 2, ≥64 μm, p < 0.05) in 6/7 cases with continuous remissions > 3 yr. Measurements of megakaryocyte size may be useful in predicting induction failure and possibly the likelihood of prolonged complete remission in adults.
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