Abstract
Five patients with acute nonlymphocytic leukemia (ANLL) with chromosomal aberrations involving bands 9q21–q22 are described. The abnormalities were an interstitial deletion in two cases of ANLL FAB type M4 and M4 with eosinophilia, a terminal deletion in two cases of M4 and M5 type ANLL, and a translocation in an M2 ANLL. A review of reported cases of ANLL with abnormalities of chromosome 9 revealed a clustering of breaks at the region 9q21–q22, suggesting a possible role for these bands in leukemogenesis.
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