Abstract
Acute hemolytic anemias due to autoantibody reactions have been observed in human beings 1 and induced experimentally in animals. 2 Hematologic examination of the experimental animals has revealed a fairly consistent pattern of morphologic change. During the initial phase of hemolysis, the mean cell diameter decreases and the mean cell volume increases, the cells assuming a spheroid shape. After several days the mean diameter rises above normal with the simultaneous appearance of macrocytes, nucleated red cells and increased numbers of reticulocytes. At this time the Price-Jones curve is frequently bimodal, and Dameshek has stressed this point as being of diagnostic import in such anemias. The recent work of Levine and his associates 3 has shown that about 90 per cent of infants with erythroblastosis foetalis have an antigen, designated as Rh, in their blood cells which is inherited from the father, probably as a mendelian dominant character, and which the
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