Abstract
The morphological changes in myocardial tissue in spontaneously hypertensive rat (SHR) occurring after administration of propylthiouracil (PTU) were assessed in the project. PTU at a concentration of 0.1% was given to the animals with drinking water for 47 days. After the end of the experiment, the morphological parameters of cardiomyocytes, the density of cardiomyocytes and fibroblasts in the myocardium, and the average area of the lumen of veins were examined. The progressive development of dystrophic processes in the myocardium was established against the background of PTU intake, which was characterized by a decrease in the cardiomyocyte density and an increase in the volume of connective tissue, venous congestion, and expansion of the lumen of veins.
Highlights
Hyperthyroidism is accompanied by damage to the cardiovascular system, which may result in the occurrence of arterial hypertension [1]
The microscopic structure of the myocardium of intact Spontaneously hypertensive rats (SHR) showed the presence of characteristic compensatory changes [8]
Loose connective tissue with numerous capillaries, oxyphilic thin collagen fibers, and fibroblasts with flat and basophilic nuclei were well identified between cardiomyocytes
Summary
Hyperthyroidism is accompanied by damage to the cardiovascular system, which may result in the occurrence of arterial hypertension [1]. Propylthiouracil (PTU) is a “drug of choice” that is used for hyperthyroidism in the first trimester of pregnancy [2]. There are facts indicating that PTU causes vasculitis and venous hyperemia of some organs [3,4,5]. The effect of PTU on the state of the myocardium is still insufficiently studied, especially if it is realized against the background of already existing pathological changes in the cardiovascular system due to hypertension. Hypertensive rats (SHR) can be used as an experimental model for this kind of research, because their pathophysiological and pathomorphological signs of hypertension are similar to those observed in the human body [6].
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