Abstract
Purpose. To study the main morphological features of the corneal endothelium in patients with pseudoexfoliative glaucoma (PEG).
 Methods. We included 193 subjects aged from 55 to 75 years. The main study group (PEG) included 96 patients (192 eyes), the primary open angle glaucoma (POAG) group included 36 patients (72 eyes) with POAG, the PEX group included 31 patients (62 eyes) with pseudoexfoliation syndrome without glaucoma. The control group consisted of 30 healthy subjects (60 eyes). Main corneal endothelium parameters were evaluated using a non-contact endothelial microscope EM-935 (Haag Streit, Switzerland). Data were analyzed by STATISTICA 9 software for Windows.
 Results. The patients with PEG had lower endothelial cell density (ECD) in comparison to the control group (p 0.01), and PEX group (p 0.05). The polymegatism level in patients with PEG and POAG was higher than in the control group (p 0.001, and p 0.01, correspondingly). In patients with moderate and advanced PEG, the ECD was significantly lower (p 0.01), and the polymegatism level was significantly higher (p 0.01) than the same parameters in patients with early PEG. The lowest ECD and the highest polymegatism percentage were observed in PEG patients with more pronounced PEX manifestations, p 0.05. No effect of IOP-lowering eye drops on the corneal endothelium parameters was revealed, p 0.05.
 Conclusions. Significant morphological changes of the corneal endothelium (decreased endothelial cell density, increased polymegatism percentage) were revealed in patients with PEG. It was established that the severity of these changes is associated with the PEG and PEX severity. No effect of IOP-lowering eye drops on the corneal endothelium parameters was detected.
Highlights
The control group consisted of 30 healthy subjects (60 eyes)
Data were analyzed by STATISTICA 9 software for Windows
The lowest endothelial cell density (ECD) and the highest polymegatism percentage were observed in pseudoexfoliative glaucoma (PEG) patients with more pronounced PEX manifestations, p < 0.05
Summary
ПЭС — псевдоэксфолиативный синдром; ПОУГ — первичная открытоугольная глаукома; ПЭГ — псевдоэксфолиа‐. Процент гексагональных клеток и полимегатизма, толщина центральной зоны роговицы у больных с начальной (I) и продвинутыми (II + III) стадиями псевдоэксфолиативной глаукомы и первичной открытоугольной глаукомы. ПЭГ — псевдоэксфолиативная глаукома; ПОУГ — первичная открытоугольная глаукома; ЦЗР — центральная зона роговицы; n — количество глаз; p1 — сравнение показателей между ПЭГ I и ПЭГ II + III. Процент гексагональных клеток и полимегатизма, толщина центральной зоны роговицы у пациентов с различной степенью выраженности псевдоэксфолиативного синдрома (псевдоэксфолиативный синдром и псевдоэксфолиативная глаукома). ПЭС — псевдоэксфолиативный синдром; ПЭГ — псевдоэксфолиативная глаукома; n — количество глаз; ПЭГ1 и ПЭС1 — группы пациентов со слабо выраженными проявлениями ПЭС, ПЭГ2 и ПЭС2 — группы пациентов с умеренно вы‐ раженными и выраженными проявлениями ПЭС; p1 — сравнение показателей между группами ПЭГ1 и ПЭГ2; p2 — сравнение показателей между группами ПЭГ2 и ПЭС2, ЦТР — центральная толщина роговицы. На рис. 1 представлен результат бесконтакт ной эндотелиальной микроскопии (ЕМ 935) и фотография переднего сегмента левого глаза пациентки 72 лет, имеющей IIа стадию псевдоэксфолиативной глаукомы
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