Abstract
Current real-time science and technology techniques based on ENDORET PRGF technologies and the implementation of their results in practical medicine, provide ample opportunities for the use of cell autotransplantation for guided tissue regeneration, including in the treatment of "disuse atrophy" of the human lower jaw bone tissue with early tooth loss. The purpose of this work is to ensure the principles of biological feasibility and physiological capacity, technical rationality. The pathology in the distal segment of a lower limb, which is a vertical atrophy of bone tissue was confirmed by the methods of computed tomography, Vatech PaX-I 3D Green systems of extra-oral radiography with a scan size range of 16×9 cm, a focal spot of 0.5 mm (IEC60336) with a gray scale of 14 bits with a size of 0.2/0.3 voxel. Using ENDORET PRGF technology, according to the approved BTI protocol, autocellular grafts that have provided a positive result that meets the basic principles of the goal in restoring the mechanisms of physiological processes of normal quantitative and qualitative morphology of bone tissue, with its biological characteristics were obtained. The results of the study showed that bone tissue on a scale of shades of gray based on the classification of Hounsfield, is not characterized by a single biotype and in the area of missing 3.6 tooth belongs to the second biotype, and in the area of missing 3.7 tooth – to the first biotype by its density. The indicators of densitometric determination confirmed excessive mineralization of the trabecular layer, ie vertical atrophy of bone tissue, which is in the sagittal section in the projection of the missing 36 teeth – with a maximum number of 881 gray standard units (GSU), M=315 GSU (where, M is the average value of absolute number); sagittal section in the projection of the missing 37 teeth – with a maximum number of 1726 GSU, M=1173 GSU. This clinical experience with the use of autocellular grafts in the treatment of "disuse atrophy" of the bone tissue of the jaws, which is essentially scientifically-research in nature, based on modern, at the same time available technologies of cell engineering and technical progress, provides a predictable result of clinical observation and deserves further research and practical testing.
Highlights
Every scientist or clinician in his professional development seeks to master and apply available universal [22, 24, 32, 46] at the same time relevant techniques in real time for the development of science and technology [8, 26] to implement their results in practical medicine
Detailed analysis of computed tomography images in sagittal sections of the segment of the lower jaw on the left, in the projection of the missing, teeth showed that bone tissue on a scale of shades of gray based on Hounsfield classification, is not characterized by one biotype and in the area of SS1 - refers to the second biotype, and in the area of SS2 refers to the first biotype by its density
Informed voluntary consent of the patient for treatment and surgery and anesthesia was obtained in accordance with the drawn up and agreed treatment plan, which provided: the stages of treatment; the anesthesia regional anesthesia; the use of autocellular grafts - guided regeneration of bone tissue using endoret prgF technology, Spain); the use of bone tissue allograft; the restoration of dentition defects using subcortical implants; the providing of a therapeutic effect and control of bone tissue mineralization and the prognosis of the formation of "biological height to width" around the implants [38]
Summary
Every scientist or clinician in his professional development seeks to master and apply available universal [22, 24, 32, 46] at the same time relevant techniques in real time for the development of science and technology [8, 26] to implement their results in practical medicine. Significant improvement of regenerative processes through the use of the patient's own blood [18, 20] is a unique product concept of autogenous, universal and safe method of application, which contains growth factors and cytokines stored in the fibrin matrix and provide stimulating properties of tissue regeneration through the processes of angiogenesis, proliferation, cell migration and Morphological features of bone tissue in "disuse atrophy" on the example of a segment of the human lower jaw:. The purpose of this work is to ensure the principles of biological feasibility and physiological capacity, technical rationality The solution to this problem is selection of treatment methods and creation of conditions for restoration of barrier [9, 30], remodeling [10] functions, and restoration of masticatory efficiency by methods of implantation [4, 16] with uniform distribution of occlusive load, formation of an oral lump (food grinding), providing phonetic and aesthetic requirements of the patient
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