Morphological examination of the possible criteria for a simple renal cyst recurrence after sclerotherapy 96° ethanol

Abstract

Nowadays kidneys’ cysts are widely spread in adult and old persons, they are usually revealed during screening ultrasonic control of population. Cysts’ sclerotherapy is one of the common mini invasive ways of their treatment. Recurrent kidney cysts appear in 12,5-33 % after sclerotherapy. The morphological signs of recurrent cysts have to be determined. Investigation of histological samples of recurrent kidney cyst (n=21) was carried out in the course of the work. The obtained data were compared with the primarily diagnosed kidneys’ cysts (n=40).For the microscopic study the histological samples were stained by hematoxilin and eosin, by the solution of alcyan blue (pH 2,6) and after Van-Gyzon. It is settled that the wall of the cyst turns thinner after conducting of sclerotherapy with 960 ethanol in comparison with the primarily diagnosed kidneys’ cyst (349,04±19,92 μm and 263,64±16,54 μm after sclerotherapy and 618±17,21 μm и 557,5±54,55 μm in compared group, respectively). This fact takes place mostly because of the enormous tissue fibrosis after sclerotherapy. The structure of the recurrent kidneys’ cyst was characterized by unequal thickness of the wall, by an enormous fibrosis, increasing of the arterial wall thickness, lymphatic vessels’ obliteration, sclerosis of the nephrogenic tissue, glomerular deformation and thickening of their walls, tubular deformation and hyaline cylinders inside, large lymphocyte’s and hemorrhagic infiltrates and hemosiderin infiltrates. Interstitial edema, which was caused by venous blood stasis and capillary thrombosis, impairs the basal membrane and interstitial fluid followed by protein component passes into the cavity of the cyst and causes the recurrent cyst development.