Abstract
One of the main issues of modern medicine, surgery, traumatology, urology, gynecology, neurosurgery, oncology, otorhinolaryngology, maxillofacial surgery is to stop the mine flow during and after surgery. In recent years, the number of local mining equipment has been increasing. This raises the question of whether these agents should be chosen based on their efficacy and safety. The value of a local anti-mine agent is limited in most studies to the study of its hemostatic effectiveness, that is, its main criterion is the question of stopping primary and secondary mining. But when using these drugs for cleaning wounds, studying the effect of the drug on soft tissues on the surface of the wound will help to positively resolve the issue of primary wound burns.
 Currently, due to the increasing exposure to anti-inflammatory substances in modern medicine, the development of new effective types of them is becoming an urgent issue. In this matter, local hemostatic drugs are of great importance. Local hemostatic drugs are used both for diffuse bleeding and for bleeding from large vessels. Today, there are various locally used hemostatic agents with different chemical compositions. Various chemical substances and their mixtures are used for their production. When checking the effectiveness of these substances, their safety level, ease of use, price and other factors are taken into account.
 Despite the large number of local mine suppressants, among them there are very few drugs that can be used universally.Therefore, the creation of highly effective local mine deterrents is an actual issue.
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