Abstract
Wistar rats were given drinking water containing 200 ppm CdCl 2 for 4 to 91 weeks and the kidneys and femoral bones were examined morphologically. Histological examination showed degenerative changes in the proximal convoluted tubules. Electron microscopically tubular changes consisted of cell edema, swelling of mitochondria, proliferation of smooth-surfaced endoplasmic reticulum, vacuolar degeneration, and coagulative necrosis. These alterations were observed to progress with increase of urinary excretion of protein and cadmium levels in the kidneys. Spontanous nephropathy was found more frequently in cadmium-exposed rats than in controls. The bones showed no significant change in histological and roentgenological examinations, as well as in assay of bone mineral content.
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