Morphological changes in the neurons of the parietal cortex and hippocampus of rats with subtotal cerebral ischemia under conditions of the use of modulators of the L-arginine-NO pathway and against the background of the administration of Omega-3 pol

Abstract

Cerebrovascular diseases of ischemic genesis tend to increase, rejuvenate, are associated with severe clinical course, high rates of disability and mortality. The urgency of the problem of cerebrovascular diseases can rightfully be defined as extraordinary, requiring the concentration of efforts of specialists of different profiles to solve it. Subtotal cerebral ischemia leads to the development of morpho functional disturbances of the cerebral cortex. The introduction of Omega-3 polyunsaturated fatty acids has a corrective effect on the hippocampus in conditions of subtotal ischemia, reducing the number of shadow cells and hyperchromic shrunken neurons, without significantly affecting the size and shape of neurons in the cerebral cortex. Prior administration of L-NAME, the use of Omega-3 did not prevent the effects of the NO synthase inhibitor and associated NO deficiency at this dose and route of administration.