Abstract
Investigating their tuberculotic patients the authors have found that the number of nephrectomies performed due to tuberculosis has shown a marked decrease since the introduction of the combined antituberculotic treatment. A comparison between the histological picture of kidneys nephrectomized without preliminary suppressive drug treatment or only given insufficient streptomycin, and that gained from nephrectomies following combined suppressive drug treatment, shows that in the latter the perifocal diffuse lymphocyte infiltration gets reduced, while in the untreated cases it is high, and the number of histiocytes increases. Of this the conclusion is drawn that the non-specific component of the inflammation also decreases as a result of streptomycin. In the cases treated there were reticular fibres in the tubercles, epitheloid cells were characteristic of the picture, and there was a decrease in the number and size of the Langhans cells. It is also considered as the result of the treatment that reticular fibrosis was replaced by collagen fibrosis. Summing up, the authors state that the combined treatment not only accelerates recovery but considerably changes the histological picture too.
Published Version
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