Abstract
A study presents the results of analysis the morphological and functional features of osteoregeneration one month and two months after the implantation of «BAK-1000» in combination with angiostimulated mesenchymal stem cells.
 Based on the analysis of specialized literature, the authors proposed the use of the «BAK-1000» implant material as an inducer of osteoregeneration, which was further enhanced by the addition of VEGF-stimulated mesenchymal stem cells to the implant.
 During the operation, which consisted of two stages, a femoral defect was created (group I) with subsequent implantation of «BAK-1000» without the addition of MSCs (group II) or in combination with autologous angiostimulated MSCs isolated at the first stage of the operation.
 Based on the revealed morphological picture of the total destruction of the «BAC-1000» apatite-silicate matrix by macrophages, moderate inflammation in the implantation area and the generation of numerous quartz crystals, the proposed method for eliminating bone tissue diastasis within two months is ineffective. However, the use of VEGF-stimulated MSCs in the developed 3D bioengineered construct induced intense angiogenesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
