Abstract
Fruit bats have been reported as the natural reservoir of many emerging and re-emerging zoonotic diseases. Infected bats usually do not show any clinical symptoms and are infected persistently. This unique characters indicate that bats have high immune activity to combat viruses even in its physiological state. High immune activity will affect the size of lymphoid organ and produce high level of reactive oxygen species (ROS). Spleen is one of the important lymphoid organ which have a strategic function in elimination of blood borne pathogens. This study was undertaken to provide information on the normal size of spleen and to analyze malonaldehyde (MDA) and super oxide dismutase (SOD) levels of free range fruit bats (Cynopterus brachyotis). The ratio of body weight/spleen was 0.4% and there were no significance differences between the male and female bats. The spleen MDA levels which represent ROS generation was higher than those of the liver. Male bats with higher levels of MDA tend to have bigger spleen size than the female which has lower MDA levels. High levels of MDA might indicate a high immune activity inside the spleen. Despite the negative effect of ROS to genetic material, high level of ROS can be advantageous to support the bats immune system as a viral reservoir. High levels of MDA are generally accompanied by high levels of SOD which might reduce the negative impact of oxidative stress in the C. brachyotis.
Highlights
Fruit bats have been reported as the natural reservoir of many emerging and re-emerging zoonotic diseases
Infected bats usually do not show any clinical symptoms and are infected persistently. This unique characters indicate that bats have high immune activity to combat viruses even in its physiological state
High immune activity will affect the size of lymphoid organ and produce high level of reactive oxygen species (ROS)
Summary
Kelelawar pemakan buah menarik perhatian peneliti karena dilaporkan berperan sebagai reservoir virus zoonotik yang saat ini bermunculan seperti sudden acute respiratory syndrome-like coronavirus; Ebola dan Marburg hemorrhagic fever filovirus, rabies dan lyssavirus yang berkaitan dengan rabies; serta banyak paramyxovirus termasuk rubulavirus, Nipah, dan Hendra (Calisher et al, 2006; Smith dan Wang, 2013; Schountz 2014; O’Shea et al, 2014; Damayanti dan Sendow, 2015; Han et al, 2015). Terdapat fakta menarik bahwa kelelawar dilaporkan memiliki kadar antioksidan yang tinggi dibandingkan manusia dan primata (Filho et al, 2007) sehingga kajian status stres oksidatif pada organ limpa sangat menarik untuk dilakukan. Keseimbangan redoks antara radikal bebas dan antioksidan endogen limpa kelelawar pemakan buah yang menentukan status stres oksidatif serta kaitannya dengan morfologi dan fisiologi kekebalannya perlu diketahui untuk pemahaman mendalam mengenai fisiologi limpa kelelawar dan status kekebalannya. Penelitian ini dilakukan untuk menganalisis dan mendokumentasikan ukuran (panjang, lebar, tebal, luas, dan bobot) limpa kelelawar pemakan buah (Cynopterus sp.) serta menganalisis dan mengaji kadar radikal bebas (MDA) dan antioksidan (SOD) organ limpa kelelawar pemakan buah untuk menentukan status stres oksidatif yang dikaitkan dengan morfologi limpa secara makroskopis dan fisiologi kekebalannya. Informasi mengenai morfofisiologi limpa nantinya diperlukan untuk membantu dalam menentukan status kekebalan kelelawar dan dapat menjadi data dasar dalam penelitian eksperimental yang menggunakan kelelawar
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
