Abstract
To the Editor: The study by Israel et al. (Aug. 8 issue),1 as reported in the Correspondence section, showed glycated hemoglobin levels that markedly underestimated glucose levels in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency among persons living in Israel. However, genetic information, which is missing in this study, is also crucial, because G6PD deficiency is an X-linked genetic disorder, and different G6PD mutations can produce a wide range of biochemical phenotypes.2 A meta-analysis of data from genomewide association studies3 involving 159,940 persons from 82 diverse cohorts of European, African, East Asian, and South Asian ancestry showed that the G6PD rs1050828 .
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