Abstract
More cases, doctor? Yes please!
Highlights
The scientific basis of modern clinical practice is founded on the randomised controlled trial [1]
Trials are needed for the registration of new drugs, vaccines and major procedures, curiously they are not necessary to register commonly used devices such as hip or knee prostheses
Induction was first systematized by Francis Bacon (1561 – 1626) in his "Novum Organum"
Summary
The scientific basis of modern clinical practice is founded on the randomised controlled trial [1]. Trials are experimental studies in which two or more selected groups (arms) which may (or may not be) "representative"of the whole population are assigned at random to one or more interventions and sometimes to an inert control (placebo) or compared to standard practice. The idea is that randomisation, if correctly applied to sufficient numbers would spread the effect of confounders across all arms of the trial.
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