Montanacin-L and montanacin-K two previously non-described acetogenins from Annona montana twigs and leaves

Abstract

A phytochemical study on Annona montana twigs and leaves led to the isolation of two previously non-described ACGs as natural products montanacin-L (1) and montanacin-K (2). Given the problems caused by synthetic insecticides there has been an upsurging on research for plant compounds for insect control. Natural annonaceous acetogenins are promising metabolites for insect control. • The chemical study of the twigs and leaves of Annona montana led to the isolation of two previously non-described ACGs. • The previously no-described compounds were evaluated for their insecticide action against Spodoptera frugiperda . • The isolation and structure elucidation of compounds 1 and 2, along with their toxicity are reported. A phytochemical study on Annona montana twigs and leaves led to the isolation of eleven annonaceous acetogenins, including two previously non-described compounds, montanacin-L and montanacin-K. Their structures were elucidated by extensive analyses of spectroscopic data (IR, UV, HRTOFMS, EI-MS and 1 H, 13 C and 2D NMR). The ACGs montanacin-L, montanacin-K, montanacin-D and montanacin-E were evaluated for their toxicity against Spodoptera frugiperda Smith (Lepidoptera: Noctuidae). Results revealed that montanacin-D and montanacin-K exhibited insecticide action.