Abstract
Infection with Pseudomonas aeruginosa in cystic fibrosis (CF) patients is a strong contributor to respiratory failure and associated mortality. Bacteria colonizing a cystic fibrosis lung commonly form biofilms that greatly contribute to increased antibiotic resistance and hypermutability.
Highlights
Cystic Fibrosis (CF) patients exhibit multiple symptoms but mortality mainly stems from debilitating pulmonary infections [1]
Analysis of reports on the efficacy of various use of antimicrobials reveal that combination therapy is more effective than monotherapy
Inclusions: Must be ≥ year 2005; Combination therapy must be compared with monotherapy; cystic fibrosis patients of all ages; in vitro or in vivo studies; in vivo studies should use an inhaled antibiotic for monotherapy, and at least one inhaled antibiotic for combination therapy; in vitro studies must use at least one antibiotic whose concentration is suitable for inhaled human use; biofilm-grown or mucoid P. aeruginosa strains that have been directly isolated from cystic fibrosis patients; prospective or retrospective; all geographical locations
Summary
Cystic Fibrosis (CF) patients exhibit multiple symptoms but mortality mainly stems from debilitating pulmonary infections [1]. Biofilm production is of particular concern as it contributes to bacterial stability and antibiotic resistance by acting as a protective barrier [7]. Infection with Pseudomonas aeruginosa in cystic fibrosis (CF) patients is a strong contributor to respiratory failure and associated mortality. Bacteria colonizing a cystic fibrosis lung commonly form biofilms that greatly contribute to increased antibiotic resistance and hypermutability. Antimicrobial treatment in these cases can be either through the use of a single agent (monotherapy) or through a combination of agents (combination therapy)
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