Abstract
Several monodentate phosphites derived from d-glucofuranose were prepared and examined as ligands in the rhodium catalysed enantioselective hydrosilylation of acetophenone. A substantial variation in the e.e. values, from racemic to 58% e.e., was seen depending on the nature of the phosphite ligand used and the ligand to metal ratio. The reactivity of the selected phosphite P(DAG) 3 towards [Rh(μ-Cl)(COD)] 2 and [Rh(μ-Cl)(C 2H 4) 2] 2 (DAG=(1:2;5:6)-di( O-isopropylidene)- d-glucofuranosyl) allowed the synthesis of monosubstitued Rh(Cl)(COD)P(dag) 3 and [Rh(μ-Cl)(C 2H 4)P(dag) 3] 2 complexes, and the disubstituted Rh(Cl)(P(dag) 3) 2 and Rh(Cl)(C 2H 4)(P(dag) 3) 2 complexes. This study indicated that the disubstituted compounds offer better enantioselectivities than the monosubstituted ones.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
