Abstract
Monocyte function has been studied in patients with lymphoma and lung cancer. Ability of monocytes to phagocytose Staphylococcus aureus was not depressed before treatment but was lowered by cytotoxic drugs. Recovery was then seen after a rest period. Bactericidal capacity was significantly lower in lymphoma patients prior to treatment than in normal controls. Chemotherapy lowered the bactericidal indices further and there was little recovery in between courses of treatment. Monocyte chemotaxis was depressed in untreated patients with advanced lung cancer and in half of a group of nineteen lymphoma patients. The implications of these monocyte defects are discussed.
Published Version
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