Monocyte chemoattractant protein-1 -2518G/A gene polymorphism and the risk of nephropathy in type 2 diabetes mellitus among Asians: a meta-analysis

Abstract

The association between monocyte chemoattractant protein-1 (MCP-1) -2518G/A gene polymorphism and the risk of nephropathy in type 2 diabetes mellitus (T2DM) remains controversial. A meta-analysis was conducted to assess the association of MCP-1 -2518G/A gene polymorphism with the risk of nephropathy in T2DM. Eight studies were included in our meta-analysis by searching electronic databases according to predefined criteria. No significant association between G allele, GG genotype, or AA genotype and the onset of nephropathy in T2DM was observed among Asians. GA genotype was significantly associated with nephropathy risk in T2DM among Asians (p = 0.024). MCP-1 -2518G/A gene polymorphism was not associated with nephropathy risk in T2DM among Chinese, Koreans, and Turks. For Indians, G allele and AA genotype were not associated with nephropathy risk in T2DM, GG genotype was associated with a lower risk of nephropathy in T2DM (p = 0.017), GA genotype was associated with the susceptibility of nephropathy in T2DM (p = 0.029). In conclusions, GA genotype might be a risk factor for the onset of nephropathy in T2DM among Asians, particularly Indians; GG genotype seems to be a protective factor against the susceptibility of nephropathy in T2DM among Indians.