Abstract
BACKGROUND: Chemokine-driven migration of inflammatory cells has been implicated in the pathogenesis of atherosclerotic conditions including peripheral arterial disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with coronary artery disease and in hypertensive patients. This study therefore investigated MCP-1 in patients with PAD. METHODS: Serum MCP-1 was determined by enzyme-linked immunosorbent assay in 36 healthy, control subjects and in 19 patients with PAD. Statistical analysis utilised the Mann-Whitney test and Spearman correlation (p < 0.05). RESULTS: MCP-1 (pg/ml) was increased in patients compared with in controls (mean+/-standard error of the mean: PAD group, 748+/-60; control group, 459+/-27; p=0.0001). MCP-1 levels tended to decrease with progressing disease. From atherosclerosis risk factors, diabetes inclined to increase MCP-1 levels; hypertension had no effect. Serum MCP-1 correlated with cholesterol, triglycerides, low-density lipoprotein but not high-density lipoprotein. Conclusion: Elevation of MCP-1 in the circulation of PAD patients shown in the present pilot study implicates this CC chemokine ligand 2 in inflammatory processes contributing to PAD clinical symptomatology. Further investigations are necessary to evaluate whether MCP-1 can be used as a potential marker of peripheral arterial disease follow-up and/or prognosis.
Highlights
Chemokines are low molecular weight polypeptides that, besides other functions, exert potent chemotactic and activating effects on specific leukocyte populations.[1]
Accumulation of mononuclear cells in the arterial intima of patients with atherosclerosis is believed to result from interplay between the trigger factors and the cell adhesion molecules, chemokines and chemokine receptors.[1]
In the present study we have concentrated on a ‘candidate’ for monocyte attraction, the chemokine Monocyte chemoattractant protein-1 (MCP-1) (CC chemokine ligand 2), in a specific form of atherosclerosis */ peripheral arterial disease (PAD)
Summary
Chemokines (chemotactic cytokines) are low molecular weight polypeptides that, besides other functions, exert potent chemotactic and activating effects on specific leukocyte populations.[1]. Chemokine-driven migration of inflammatory cells has been implicated in the pathogenesis of atherosclerotic conditions including peripheral arterial disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with coronary artery disease and in hypertensive patients. This study investigated MCP-1 in patients with PAD. Results : MCP-1 (pg/ml) was increased in patients compared with in controls (mean9/standard error of the mean: PAD group, 7489/60; control group, 4599/ 27; p /0.0001). Diabetes inclined to increase MCP-1 levels; hypertension had no effect. Conclusion : Elevation of MCP-1 in the circulation of PAD patients shown in the present pilot study implicates this CC chemokine ligand 2 in inflammatory processes contributing to PAD clinical symptomatology. Further investigations are necessary to evaluate whether MCP-1 can be used as a potential marker of peripheral arterial disease follow-up and/ or prognosis
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