Changes and implication of peripheral blood levels of BNP and MCP-1 in patients with coronary heart disease

Abstract

Objective To investigate the change of peripheral blood levels of B-type natriuretic peptide(BNP)and monocyte chemoattractant protein-1 (MCP-1)in patients with coronary heart disease,and explore their relationship.Methods Plasma BNP and MCP-1 levels were measured in 20 patients with acute myocardial infarction(AMI group),18 patients with unstable angina(UA group),19 patients with stable angina(SA group)and 17 normal control subjects(control group)by ELISA.Results (1)The levels of BNP,MCP-1 in AMI,UA group were significantly higher than those in SA group and control group.(2)The levels of BNP were significantly different between UA group and AMI group,but the levels of MCP-1 had no significant difference between UA group and AMI group.(3)There was significant correlation between integral of coronary stenosis and BNP level(r=0.716,P＜0.01),and the integral of coronary stenosis had no sisnificant correlation with the level of MCP-1.There was significant correlation between the levels of BNP and MCP-1 in AMI group and UA group(r=0.625,P＜0.01).Conclusions The increased levels of BNP and MCP-1 in patients with coronary heart disease may predict the unstable conditions of plaques.The fact that there is obvious correlation between BNP and MCP-1 suggests that different aspects predict the unstability of plaques.It may be more beneficial in predicting the stability of atherosclerosis plaques and forecasting acute cardiovascular risk by combination detection of serum levels of BNP and MCP-1. Key words: Coronary disease; Natriuretic peptide,brain; Chemokine CCL2