Abstract
Abstract Whole red cells, red cell membranes or soluble blood group substances prepared from individuals with blood group A 1 , A 2 , B or A 2 B were used as immunogens. A large number of mouse-mouse hybridomas with anti-A, anti-B and anti-A, B specificity was produced. Several of these antibodies were shown to be superior to human polyclonal testsera both in manual and in automated blood grouping. Spleen cells from mice immunized with a synthetic antigen containing the oligosaccharide lacto- N -difucohexaose I were fused with Sp2/0 cells and yielded a number of hybridomas which produced antibodies with anti-Le b specificity. One of these antibodies was capable of agglutinating Le b cells from all ABO groups and is therefore classified as an anti Le bL .
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