Abstract
We used a novel phase-resolved optical Doppler tomographic (ODT) technique, with very high flow velocity sensitivity (10 μm/s) and high spatial resolution (10 μm), to image blood flow in port wine stain (PWS) birthmarks in human skin. The variance of blood flow velocity is used to locate the PWS vessels in addition to the regular ODT images. Our device combines an ODT system and laser so that PWS blood flow can be monitored in situ before and after treatment. To our knowledge, this is the first clinical application of ODT to provide a fast semi-quantitative evaluation of the efficacy of PWS laser therapy in situ and in real-time.
Highlights
Numerous methodologies have been investigated in search of the ideal blood flow imaging technique for human skin, including fluorescein injection, isotopic clearance, angioscopy and angiography, electromagnetic flowmetry, interstitial fluid pressure, transcutaneous PO2 reflective photoplethysmography, dermofluorometry, magnetic resonance imaging, and temperature probes
We have recently developed a novel phase-resolved optical coherence tomography (OCT)/Optical Doppler Tomography (ODT) system that uses phase information derived from a filbert transformation to image blood flow in human skin with fast-scanning speed and high velocity sensitivity [4]
This is important because the laser energy density must be controlled such that only the targeted port wine stain (PWS) blood vessels are destroyed while sparing adjacent skin structures
Summary
Numerous methodologies have been investigated in search of the ideal blood flow imaging technique for human skin, including fluorescein injection, isotopic clearance, angioscopy and angiography, electromagnetic flowmetry, interstitial fluid pressure, transcutaneous PO2 reflective photoplethysmography, dermofluorometry, magnetic resonance imaging, and temperature probes. The exceptionally high spatial resolution of ODT allows noninvasive imaging of both in vivo blood microcirculation and tissue structures surrounding the vessels. We have recently developed a novel phase-resolved OCT/ODT system that uses phase information derived from a filbert transformation to image blood flow in human skin with fast-scanning speed and high velocity sensitivity [4]. The noninvasive nature and high spatial resolution of ODT should have many applications in the clinical management of patients in whom imaging blood flow in human skin is required. Vol 3915 (2000) 1605-7422/00/$15.00 application of ODT to characterize and image blood flow with high spatial resolution at discrete userspecified locations in highly scattering human skin has been demonstrated
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