Abstract
We used a novel phase-resolved optical Doppler tomographic (ODT) technique with very high flow-velocity sensitivity (10microm/s) and high spatial resolution (10microm) to image blood flow in port-wine stain (PWS) birthmarks in human skin. In addition to the regular ODT velocity and structural images, we use the variance of blood flow velocity to map the PWS vessels. Our device combines ODT and therapeutic systems such that PWS blood flow can be monitored in situ before and after laser treatment. To the authors' knowledge this is the first clinical application of ODT to provide a fast semiquantitative evaluation of the efficacy of PWS laser therapy in situ and in real time.
Highlights
Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood f low Yonghua Zhao, Zhongping Chen, Christopher Saxer, Qimin Shen, Shaohua Xiang, Johannes F. de Boer, and J
We recently developed a novel phase-resolved optical coherence tomography (OCT)/Optical Doppler tomography1 – 3 (ODT) system that uses phase information derived from a Hilbert transformation to image blood f low in human skin with fast scanning speed and high-velocity sensitivity.[1,4]
The minimum blood f low velocity that can be detected in human skin while simultaneously maintaining a spatial resolution of 10 mm is as low as 10 mms
Summary
Title Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow. Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood f low Yonghua Zhao, Zhongping Chen, Christopher Saxer, Qimin Shen, Shaohua Xiang, Johannes F. de Boer, and J.
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