Abstract
Monitoring in vivo and in real time the influence of selective antisense on GABAA receptors in rat brain
Highlights
The influence of GABA upon sleep is well known [1]
The microinjection of the respective antisense oligonucleotide [obtained from Thermo Fisher Scientific U.S.A.] into the medial preoptic area of the rat brain caused a significant increase in sleep time
The data gathered in these experiments indicate a direct In vivo effect of oligonucleotide antisense upon neurotransmitter activities as well as cell firing
Summary
The influence of GABA upon sleep is well known [1]. In particular, the role of the GABAA receptors is well established [2]. The present experiments have been undertaken to observe i] the feasibility of monitoring In vivo eventual direct influence of specific antisense oligonucleotide of GABAA receptors upon physiological parameters such as sleep duration as well as ii] presynaptic and post synaptic activities via electrochemical analysis of neurotransmitters and cell firing.
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