Abstract
(+)-Haedoxan A, an insecticidal sesquilignan, inhibited the specific binding of the noncompetitive GABA antagonist [35S]t-butylbicyclophosphorothionate (TBPS) to rat brain membranes in concentration-dependent and noncompetitive manners. The data show haedoxan’s interaction with a site coupled to the TBPS-binding site on the GABAA receptor in rat brain, while the physiological significance of the interaction remains to be discovered.
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