MON-061 Association between the ratio of serum eicosapentaenoic acid or docosahexaenoic acid to arachidonic acid and life expectancy in hemodialysis patients

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It is reported that n-3 polyunsaturated fatty acids as represented by eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) ameliorates the incidence of cardiovascular disease (CVD) event in population with dyslipidemia and that a higher serum EPA/AA (eicosapentaenoic acid to arachidonic acid) ratio is associated with a lesser risk of CVD event in a general Japanese population. On the contrary, it is well known that CKD itself contributes to the incidence of CVD event and life expectancy, however, the association between the ratio of serum EPA/AA or DHA/AA and the incidence of CVD event or life expectancy in hemodialysis patients remains to be investigated. 84 hemodialysis patients at our dialysis unit were examined on January, 2014. Along with regular blood examination at the beginning of the month, fatty acid four fractions (EPA, DHA, DHLA, AA) were collected. Also age, sex, dialysis-duration, clinical histories and existence or nonexistence of the administration of EPA/DHA-drug product were examined in the medical cords. The life expectancy was followed for three years prospectively. EPA/DHA-drug product was administered to only two patients, all the rest patients took no EPA/DHA-drug product. Comparing between patients with or without the administration of EPA/DHA-drug product, there was no significant difference in DHA/AA ratio, on the other hand, there was significant difference in EPA/AA ratio (the former: 1.58 vs the latter: 0.49) as well as in EPA+DHA/AA ratio. Hereinafter, the data was investigated on patients with the administration of EPA/DHA-drug product. On univariate analysis, there was significant positive correlation between age and the three ratios, respectively, however no correlation between clinical histories and the three ratios. On logistic regression analysis, there was significant positive correlation between age and EPA/AA or EPA+DHA/AA ratio, respectively. There was significant correlation between three-year life expectancy and the three ratios, respectively. Our findings suggest that a higher serum EPA/AA and/or DHA/AA ratio is associated with a better life expectancy in hemodialysis patients.