Abstract
The relationship between gas-liquid chromatographic (GLC) retention properties and R F values in thin-layer chromatography (TLC) with molecular connectivity indices, m X t, was investigated for a series of benzodiazepines using multiple correlation coefficients, standard errors of estimate, F-Snedecor function values and Student's t-test as the criteria for best equation selection. Regression analyses show that the molecular connectivity model predicts the retention properties in GLC with the polar stationary phase OV-17 at 280°C and the R F values in TLC with the stationary phase silica gel. However, zero- or second-order connectivity indices alone are not sufficient; higher-order indices are shown to be necessary. The effect of the polarity of the mobile phases in TLC was also investigated.
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