Abstract
Gas-liquid chromatographic (GLC) retention indices of 31 aniline derivatives were measured on six columns of different polarity. Relationships between reversed-phase thin-layer chromatographic (TLC) R M values, log P values and GLC retention data (retention indices extrapolated to 0°C and retention index differences measured on different columns) were investigated by stepwise regression analysis. Significant relationships were found in only a few instances but the regression coefficients were not high enough for predicting lipophilicity. A dependence of the relationship between lipophilicity and retention data on the type of compounds was observed and difficulties with GLC as a technique for determining lipophilicity are emphasized. The influence of TLC systems on R M values, the influence of organic solvents on the partition coefficients and the influence of temperature and stationary phases on GLC retention indices are discussed.
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