Abstract
Magnetic resonance imaging (MRI) is a powerful non-invasive diagnostic tool that can provide important insights for medical treatment monitoring and optimization. Photodynamic therapy (PDT), a minimally invasive treatment for various types of tumors, is drawing increasing interest thanks to its temporal and spatial selectivity. The combination of MRI and PDT offers real-time monitoring of treatment and can give significant information for drug-uptake and light-delivery parameters optimization. In this review we will give an overview of molecular theranostic agents that have been designed for their potential application in MRI and PDT.
Highlights
Introduction to the Theranostic ApproachTheranostics is an innovative medical treatment research field which incorporates the functions of therapy and diagnostics by imaging and paves a way for personalized medicine [1,2,3,4]
magnetic resonance imaging (MRI)-guided photodynamic therapy (PDT) can be realized with repeated contrast agent injection at different time points
Porphyrin-Gd-Complexes Conjugates with Potential MRI and PDT Applications accumulate in cancer cells and/or their relaxivity have been studied
Summary
Theranostics is an innovative medical treatment research field which incorporates the functions of therapy and diagnostics by imaging and paves a way for personalized medicine [1,2,3,4]. Theranostic agents combine an imaging agent and a therapeutic agent within the same scaffold, both agents being delivered at the same time and with the same biodistribution. They give important information for pre-treatment planning, therapy monitoring, and treatment outcome assessment, and, for the development of new therapeutic agents. We review molecular theranostic agents combining magnetic resonance imaging (MRI) and photodynamic therapy (PDT) applications. These multifunctional molecules can be described as low and medium molecular weight compounds that do not self-assemble into bigger systems. Theranostic agents based on nanoparticles belong to another promising and active field and have recently been reviewed [5,6,7]
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